Alzheimer’s disease is the most common cause of senile dementia, which affects many millions of people worldwide. These short movies demonstrate amyloid plaques and neurofibrillary tangles, the two most significant pathological hallmarks of Alzheimer-type dementia, in three-dimension.
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Movie 1: Amyloid plaques around cortical pyramidal neurons
Tissue/pathology:
Neocortex, layer III of Brodman 4 region from a terminal phase (Braak 6, Thal 4) Alzheimer’s disease subject
Antibodies:
SMI32 (green)
β-amyloid (red)
Movie description:
Note the large pyramidal neurons (green, SMI32 as marker) and the dense amyloid plaques (red) throughout in the neocortex of an Alzheimer’s disease subject.
Movie 2: Tau cytoskeletal pathology in the locus coeruleus
Tissue/pathology:
Locus coeruleus from a subject with mild cognitive impairment (Braak 3, Thal 2).
Antibodies:
Tyrosine hydroxylase (white-bluish)
Hyperphosphorylated tau (AT8, red)
Movie description:
This movie shows the medial part of the human locus coeruleus (ca 6 mm rostro-caudally) from a subject with mild cognitive impairment. Note the dense tau cytoskeletal pathology (visualized by AT8 antibody) throughout the entire nucleus. Also see: locus coeruleus-tau project.
