The pancreas is an abdominal organ with digestive and endocrine functions. Endocrine cell groups called Langerhans islets in the pancreas produce insulin and glucagon, two key hormones that control blood sugar levels. This short movie demonstrates the three-dimensional distribution of Langerhans islets as well as the complex sympathetic (noradrenergic) innervation of the mouse pancreas.
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Movie 1: Pancreas Langerhans islets and sympathetic nerves
Tissue/pathology:
Young adult male C57BL/6J control mouse pancreas
Antibodies:
Tyrosine hydroxylase (TH, red)
Insulin (green)
Movie description:
This movie shows a ca. 4 x 4 x 4 mm piece of the healthy mouse pancreas with insulin (green) and tyrosine hydroxylase (red) volume immunostaining. Insulin staining depicts the Langerhans islets in 3D, while the TH staining shows the complex sympathetic (noradrenergic) innervation of the organ as well as the sparse TH+ cells within the islets.
