Alzheimer’s disease (human)
Movie 1: Amyloid plaques around cortical pyramidal neurons
Tissue/pathology:
Neocortex, layer III of Brodman 4 region from a terminal phase (Braak 6, Thal 4) Alzheimer’s disease subject
Antibodies:
SMI32 (green)
β-amyloid (red)
Movie description:
Note the large pyramidal neurons (green, SMI32 as marker) and the dense amyloid plaques (red) throughout in the neocortex of an Alzheimer’s disease subject.
Download high. res. video 请登录哔哩哔哩观看。Movie 2: Tau cytoskeletal pathology in the locus coeruleus
Tissue/pathology:
Locus coeruleus from a subject with mild cognitive impairment (Braak 3, Thal 2).
Antibodies:
Tyrosine hydroxylase (white-bluish)
Hyperphosphorylated tau (AT8, red)
Movie description:
This movie shows the medial part of the human locus coeruleus (ca 6 mm rostro-caudally) from a subject with mild cognitive impairment. Note the dense tau cytoskeletal pathology (visualized by AT8 antibody) throughout the entire nucleus. Also see: locus coeruleus-tau project.
Download high. res. video 请登录哔哩哔哩观看。Tissue: Dr. Zsofia Magloczky, Prof. Gabor G. Kovacs;iDISCO reaction, light sheet microscopy, postprocess and videos: Dr. Csaba Adori