Recently, we described that the hepatic sympathetic innervation undergoes selective and progressive disintegration and degeneration in an experimental model of metabolic dysfunction-associated fatty liver disease (MAFLD). In collaboration with Prof. Tore Bengtsson from the Department of Molecular Biosciences at Stockholm University and in partnership with the pharmaceutical company Atrogi, we replicated these findings in an alternative experimental mouse model of MAFLD. Our current research aims to investigate the potential of chemical compounds in ameliorating these pathological conditions and in regenerating the hepatic sympathetic fibers. Furthermore, we intend to expand our investigations to encompass other peripheral organs such as the pancreas as well.

Trimmed and degenerating hepatic sympathetic (noradrenergic) nerve pathology in high fat, fructose and cholesterol (HFFrC) diet mouse model of NAFLD, tyrosine hydroxylase volume immunostaining. Diet and dissections: Gopala Krishna Yakala. Volume immunostaining and iDISCO clearing: Elisabeth Verboven and Csaba Adori. Light sheet microscopy: Csaba Adori.