In collaboration with Prof. Gabor G. Kovacs (University of Toronto, Canada), we study synuclein pathology and tau co-pathology in the human locus coeruleus-pericoerulear complex in various stages of Parkinson’s disease in 3D.
Synuclein pathology in human noradrenergic neurons. Tyrosine-hydroxylase (gray) + pathological synuclein (pS129-aSyn, red) volume co-immunostaining on dewaxed brain sample from a subject with Lewy-body disease (LBD) and progressive supranuclear palsy (PSP) co-pathology, medulla, A1 noradrenergic cells. Sample: prof. Elisabet Englund (University of Lund); volume immunostaining, light sheet microscopy and image processing: Csaba Adori.