In collaboration with Dr. Bence Rethi (Karolinska Institutet Department of Medicine; Uppsala University, Department of Pharmacy) we study the 3D distribution of rheumatoid arthritis autoantibodies in a mouse model.
Visualization of i.v. injected fluorochrome-conjugated control IgG2a in the mouse ankle (pink: injected antibody; grey: tissue autofluorescence). Injection and sample: Marcelo Gomes Afonso and Bence Rethi; light sheet microscopy and image processing: Csaba Adori.